ABSTRACT
Abstracts: Background: Pain results from complex interactions in peripheral and central synapses.1The majority of current approaches to treating pain are based on the idea that increasing the level of inhibitory drive or tone at key central nervous system (CNS) regions in the pain pathway can alter pain perception2,3,4,5 Lot of neurotransmitters are implicated in it including 5-HT. Thus we were interested If buspirone is having analgesic effect.Our aim was to assess if buspiron has analgesic effect. And if comparative efficacy to drugs used today. Methodology: After appropriate IAEC clearance ,Hotplate , tail flick analgesiometer methods and acetic acid writhing test were employed. Comparative drugs used were amitriptyline and ibuprofen . Buspirone was used in doses of 2,4 ,mg/kg. Results: Our study showed a comparable efficacy of buspirone to ibuprofen in hot plate test while superior efficacy as an analgesic against amitriptyline at dose of 4mg/kg. Conclusion: 5-HT is considered pronociceptive but has shown differential activity in CNS and at peripheral tissues. Buspirone is a partial 5-HT 1A agonist and antianxiety drug. Due to the complex interactions at centers in CNS it was proposed to have analgesic action.Our study evaluated this theory with three analgesic models. Our results show that at doses 2 & 4mg/kg it has comparable effect to ibuprofen 20 mg/kg dose. At the same dose it shows superiority to amitriptyline 40mg/kg. Thus it shows promise in treatment of pain associated with anxiety induced depression or other psychiatric problems.